The French international withdrew after playing Victor Lindelof, apparently after injuring his right thigh.
World Cup winner Fred was replaced.
Pogba was at his best form in Manchester United This season’s shirt, it has appeared 27 times in all competitions.
Pogba was top scorer in United’s last win Burnley, As the Red Devils ran out of 1-0 winners over Turf Moor to temporarily climb to the top of the table.
Pogba was also on United’s goal in their victory over the relegation warrior Fulham In January, the Red Devils scored their second goal as they came back from behind to win 2-1.
Ole Gunnar Solskjaer brought the Frenchman back to rest the last time as Man United won 9-0 Southampton.
But the midfielder returned to United’s starting line-up for a match Everton at home.
He was unable to reach the first half, after he pulled suddenly and immediately signaled to the seat that he needed to make way.
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